화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터)
권호 42권 1호
발표분야 의료용 고분자 부문위원회 I
제목 Preparation of biocompatible PLGA/inorganic composites for bone implants
초록 PLGA has been widely used as biomedical applications due to their biodegradability and biocompatibility. However, PLGA degradation products are known to decrease the pH in the surrounding tissue, thus causing local inflammatory reaction. Moreover, it can be required to enhance mechanical property and biocompatibility for use as load-bearing bone implants. In this study, we developed the PLGA/inorganic composites with Mg(OH)2 and β-TCP that induce pH neutralizing effect and osteoconductivity, respectively. Inorganic particles were uniformly blended in melted polymer via a twin extrusion process. PLGA blends were characterized by using GPC, TGA, DSC, UTM and FE-SEM. Also, the in vitro degradation of composites was examined in PBS solution (pH 7.4) at 50 °C. From the results, the modulus of PLGA/inorganic composites increased compared to PLGA composite, and Mg(OH)2 particles in the composites effectively reduce inflammation caused by PLGA degradation induced acidic environment.
저자 이슬기1, 유정주2, 김익환1, 정윤기2, 한동근1
소속 1한국과학기술(연), 2고려대
키워드 Bone; PLGA; β-tricalcium phosphate; magnesium hydroxide; anti-inflammation
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