화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터)
권호 42권 1호
발표분야 의료용 고분자 부문위원회 I
제목 Synthesis of Folate-functionalized Porous Nanoparticles using Reactive Surfactant
초록 Folate-conjugated polymers can combine with the folate receptor protein(FR), which is present commonly on the surface of many human cancers. Poly vinyl ketones, photodegradable polymers by Norrish reactions, and its copolymers have been used as packing materials, agricultural film and functional materials. In this study, oligo ethylene glycol methacrylate with trithiocabonate was used as reactive surfactant. Emulsion RAFT polymerization was conducted with methyl vinyl ketone, styrene and the reactive surfactant to obtain polymer nanoparticles. The polymer nanoparticles were irradiated with UV light and modified with folic acid. The reactive surfactant and nanoparticles were characterized by NMR, FT-IR, TEM and so on, and cell uptake study of the folate-functionalized porous nanoparticles were evaluated.
저자 김태윤, 정일두
소속 부산대
키워드 Folate; Emulsion RAFT; Photodegradable polymer; Porous polymer
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