화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터)
권호 42권 1호
발표분야 기능성 고분자
제목 Simultaneous delivery of siRNA and anticancer drug via multiple monocomplexation-induced hydrophobic association
초록 The widely studied strategy of synergetic delivery of siRNA and anticancer drugs for cancer treatment has clinical potentials, but it still has important issues such as delivery efficiency or biocompatibility of the siRNA delivery system. In this study, we present a simple and biocompatible colloidal formulation, i.e. hydrophobically associated multiple monocomplex (HMPlex) (<10 nm in hydrodynamic size) consisting of Bcl-2 gene targeting siRNA, anticancer agent (BZT, benzethonium chloride) and Pluronic F-68 with low charge ratio (N/P = 8). It was demonstrated by in vitro studies using various cell lines that HMPlex containing siRNA and BZT efficiently led to both mRNA down-regulation by siRNA and cell apoptosis by BZT, compared to non-targeting HMPlex with scrambled siRNA and a non-toxic cationic surfactant.
저자 유원재1, 최은실2, 박재형2, 김세훈1
소속 1성균관대, 2한국과학기술(연)
키워드 siRNA; Synergetic delivery; Bcl-2; apoptosis
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