화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터)
권호 41권 1호
발표분야 의료용 고분자 부문위원회 I
제목 Comparision of Serum Half-life Extension Between PEGylated and Albuminated Proteins in Animal Studies
초록 The poly(ethyleneglycol) (PEG)-therapeutic protein conjugates are widely used as drug delivery. However, the anti-PEG antibodies raise concerns about the PEGylated therapeutics application [1]. Compared to the PEG-conjugation, conjugation of human serum albumin (HSA) is an attractive emerging strategy for the extension of the serum half-life of a therapeutic protein [2]. To clarify whether the site-specific albumination is an effective strategy, alternative to PEGylation, comparision of serum half-life extension is required. However, the serum half-lives of PEGyalted and albuminated proteins have not been directly compared. In this study, We achieved that the site-specific PEG- or HSA-conjugation to superfolder green fluorescent protein (sfGFP) and then, compared their serum half-lives.
저자 양병섭, 권인찬
소속 광주과학기술원
키워드 bioconjugation; PEGylation; albumination; serum half-life; non-natural amino acid incorporation; click chemistry
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