화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터)
권호 41권 1호
발표분야 의료용 고분자 부문위원회 I
제목 Hyaluronic acid-based theranostic nanoparticles for activatable imaging and therapy of cancers and inflammatory diseases
초록 Theranostic nanomedicines for simultaneous diagnosis and therapy of various diseases have received a great deal of attention. In this presentation, I am going to introduce hyaluronic acid-based theranostic nanomedicines, which have been recently developed in my lab. Hyaluronic acid (HA), an anionic glycosaminoglycan with repeating carboxylic acid groups, is abundant in humans, especially in the extracellular matrix. It could be served as polymeric backbone for bioconjugation, substrate for enzymatic and oxidative degradation, and mediator for pH-responsive drug delivery. Based on these properties of HA, we developed redox-, enzyme-, and pH-responsive theranostic nanoparticles for imaging and subsequent therapy of cancers and activated macrophages.
저자 최용두, 박동진, 김현진, 정경채, 고성호, 조영남
소속 국립암센터
키워드 Theranostics; nanomedicine; cancer; hyaluronic acid
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