화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO))
권호 40권 2호
발표분야 의료용 고분자 부문위원회 II
제목 pH-Responsive Polymeric Nanocarrier Based on Hyaluronic acid for Treatment of Rheumatoid Arthritis
초록 Self-assembled hyaluronic acid nanoparticles (HANPs) have potential as drug carriers for rheumatoid arthritis (RA) since HA specifically binds to the receptor (CD44) which is over-expressed in the inflammatory site by RA. In this research, we prepared the HA derivative with the linkage that is degradable in the acidic condition such as the inflamed joint of RA. The hydrophobic drug, methotrexate (MTX), was efficiently encapsulated into HANPs. The results show that MTX is rapidly released under the acidic condition after HANPs reach the inflammatory site. The characteristics of pH-responsive HANPs were confirmed using 1H-NMR and DLS. In vitro study indicated that pH-responsive HANPs were efficiently taken up by RAW 264.7 cells. From in vivo experiment, it was confirmed which pH-responsive HANPs were selectively accumulated at the inflammatory joint of collagen-induced arthritis mice model. These results imply that pH-responsive HANPs have potential as drug carrier for treatment of RA
저자 박재형, 이민창, 허로운, 전주은
소속 성균관대
키워드 Hyaluronic acid; pH-responsive; nanocarrier; Rheumatoid Arthritis
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