화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터)
권호 40권 1호
발표분야 의료용 고분자 부문위원회 II
제목 Anisotropic biodegradable nanoparticles of stereocomplexes of enantiomeric poly(lactide)-poly(ethylene glycol) triblock copolymers
초록 Anisotropic biodegradable nanoparticles have been of great interest because they offer unique properties by asymmetric distribution of polymers at each compartment. In this study, three different ABA-type triblock copolymers of (1) poly(l-lactide)-poly(ethylene glycol)-poly(l-lactide), PLLA-PEG-PLLA, (2) poly(d-lactide)-PEG-poly(d-lactide), PDLA-PEG-PDLA, and (3) poly(glycolide)-PEG-poly(glycolide), PGA-PEG-PGA were synthesized and characterized. Depending on crystalline and amorphous state, a series of anisotropic biodegradable nanoparticles were prepared via electrohydrodynamic co-jetting. One compartment was composed of stereocomplexes formed by enantiomeric PLLA-PEG-PLLA and PDLA-PEG-PDLA while the counterpart being composed of PGA-PEG-PGA. Different swelling ratios and degradation rates enable them to show different drug release kinetics. In conclusion, anisotropic biodegradable nanoparticles would be promising for advanced drug delivery system.
저자 강현기1, 황은영2, 임동우3
소속 1Department of Bionano Engineering, 2Hanyang Univ., 3ERICA Campus
키워드 Anisotropy; Biodegradable nanoparticles; Electrohydrodynamic co-jetting; Stereocomplexes; Drug delivery system
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