화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터)
권호 40권 1호
발표분야 기능성 고분자
제목 Fluorescent inorganic/organic hybrid system composed of mesoporous silica nanoparticles and conjugated polymer dots for protease detection
초록 Recently, diverse functionalized mesoporous silica nanoparticles (MSNs) using polymers, dendrimers or large molecules as capping agents have been subjected to great attention for drug delivery materials or sensors. However, MSNs containing peptides as the capping agents have not been reported. Therefore, we prepared fluorescent hybrid system (FHS) for protease, composed of polyarginine capped MSNs fused with conjugated polymer dots (CPdots) by electrostatic interaction. Trypsin is an important digestive enzyme fabricated in the pancreas. Particularly, trypsin is one of enzymatic proteins degrading selectively peptide, such as lysine and arginine. CPdots were released from MSNs containing anthracene via degradation of polyarginine linker by trypsin. FHS was able to give fluorescence signal change via prevention of energy transfer between anthracene (energy donor) included in the pores of MSNs and CPdots by the presence of trypsin
저자 김종호, 김대근, 이택승
소속 충남대
키워드 conjugated polymer nanoparticle; FRET; mesoporous silicananoparticle; trypsin
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