화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2014년 가을 (10/06 ~ 10/08, 제주 ICC)
권호 39권 2호
발표분야 의료용 고분자 부문위원회
제목 Biomedical applications of functional proteins containing non-natural amino acids
초록 Advances in recombinant DNA techniques allow practical production of recombinant proteins from genetically engineered bacteria, yeast, or mammalian cells. Recombinant functional proteins including therapeutic proteins and biomaterials have been used for various biomedical applications. However, broader application of proteins has been hindered by the limited number of building blocks. In order to overcome this restriction, several techniques to incorporate non-natural amino acid building blocks into proteins were developed. Two biomedical applications of proteins containing non-natural amino acids will be presented. First, PEG molecules were conjugated into artificial extracellular matrix proteins containing non-natural amino acids via click chemistry. Second, site-specific fatty acid-bioconjugation to (therapeutic) proteins was achieved to prolong the serum half-life in vivo using site-specific incorporation of a reactive non-natural amino acid.
저자 권인찬
소속 광주과학기술원
키워드 protein; non-natural amino acids
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