화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2014년 가을 (10/06 ~ 10/08, 제주 ICC)
권호 39권 2호
발표분야 의료용 고분자 부문위원회
제목 Gelatin Based Blend System Hydrogel for Islet Cell Carrier
초록 To treat type 1 diabetes characterized by the autoimmune destruction of the β-cells, several studies report some possible candidates. In cell delivery system, especially, it is essential to avoid immune response after transplantation. In this respect, hydrogel is considered as a great cell reservoir due to its high water contents. Also, to minimize surgical process, hydrogels which can be injected into body using syringe are required. In this study, we designed gelatin based injectable hydrogel. Among many biopolymers, we decided to use gelatin because it has a lot of RGD sequences in its content, so it is expected that the gelatin containing hydrogel can enhance cell adhesion. By blending oppositely modified gelatin, we confirmed the gelation behavior and also found that the hydrogel using this system is injectable by shear thinning property. Finally, we applied this hydrogel into islet cell carrier to monitor the high glucose level by in vivo experiment.
저자 이승용, Muhammad R. Haque, 변영로, 안철희
소속 서울대
키워드 hydrogel; islet; cell delivery; diabete mellitus
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