화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2014년 가을 (10/06 ~ 10/08, 제주 ICC)
권호 39권 2호
발표분야 의료용 고분자 부문위원회
제목 Bioreducible robust hyaluronic acid nanoparticle for tumor-targeted delivery of doxorubicin
초록 Self-assembled nanoparticles, composed of amphiphilic HA derivatives, have emerged as promising anticancer drug carrier because they can specifically binds to HA receptor (CD44) over-expressed on cancer cells. Despite their tumor-targetability, stability of the nanoparticles in the blood stream still remains a major challenging issue for their in vivo applications. In this study, to improve the stability of nanoparticles we have prepared disulfide crosslinked HA-nanoparticles (CL-HANPs) from pyridyldisulfide bearing HA-b-poly(caprolactone) (HA(PDA)-b-PCL) copolymers via a facile crosslinking method. From the in vitro characterization and in vivo biodistribution, we demonstrated the enhanced structural stability and robust release of drugs. Overall, these results suggest that CL-HANPs might be a promising carrier for intracellular delivery of hydrophobic anticancer drugs with minimum side effects.
저자 한화승, 고혜원, 전주은, 박재형
소속 성균관대
키워드 Hyaluronic acid; drug delivery; stimuli-sensitive nanoparticle
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