화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2014년 봄 (04/30 ~ 05/02, 제주국제컨벤션센터)
권호 18권 1호
발표분야 신진과학자포럼
제목 Microvascular Stamp for Patterning of Functional Neovessels
초록 In the past, extensive efforts have been made to control the growth direction and the spacing of neovessels because of their critical roles in homeostasis, pathogenesis and regeneration of tissue. However, no success has been achieved to regulate the physiologically relevant micro-scale spacing between functional neovessels through which blood flows, and this has been a grand challenge for tissue engineers and biomedical scientists for many years. Here, we present a novel strategy for constructing a new living microvascular stamp which releases multiple angiogenic factors and subsequently creates neovessels with the same micrometer scale pattern as that engraved in the stamp using a stereolithographic assembly unit.   Thus, controlling the ‘bottom-up’ emerging behavior of the neovessel formation via 'directed top-down’ cues using the living microvascular stamp is a major step forward to better understand vascular biology and also improve quality of a variety of clinical treatments necessitating the neovascularization.
저자 정재현
소속 숭실대
키워드 Neovessels; Patterning; Hydrogel; Alginate
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