화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터)
권호 39권 1호
발표분야 의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능)
제목 Fabrication and characterization of PLGA / γ-PGA nerve conduits by thermally induced phase separation
초록 The Peripheral nervous system (PNS) regeneration can be improved by nerve conduits. The purpose of this study was to design a more effective neural guidance conduit, to treat peripheral nerve into the conduit, and to determine regenerative capability through it in an in vitro model. A novel, fully biodegradable polymer conduit was designed and fabricated for use in peripheral nerve repair, which approximates the macro and microarchitecture of native peripheral nerves. A uniform shape based on poly(lactic-co-glycolic acid) (PLGA) and poly(γ-glutamic acid) (γ-PGA) has been prepared via a thermally induced phase separation technique using a mixture of dimethyl sulfoxide as solvent. The better nerve regeneration behavior in our nerve conduits may be caused by the effect of the asymmetrically porous tube with hydrophilicity, and structural stability, which can provide good environment for nerve regeneration and stimulation of the schwann cells.
저자 이정희, 김영진
소속 대구가톨릭대
키워드 Peripheral nerve regeneration; Nerve conduit; Phase separation
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