화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2013년 가을 (10/23 ~ 10/25, 대구 EXCO)
권호 19권 2호, p.1477
발표분야 분리기술
제목 In-line monitoring of anti-solvent co-crystallization based on NIR spectroscopy
초록 Co-crystals are being intensively studied nowadays primarily due to the potential of improving pharmaceutical properties including the dissolution behavior for BCS class-II drug substances such as indomethacin (IMC). Recently, we discovered a new method using anti-solvent addition method to prepare indomethacin-saccharin (IMC-SAC) co-crystals. In this study, we investigated the kinetic pathways in the phase solubility diagram during the cocrystallization process. The process monitoring was carried out using in-line NIR spectroscopy, which predicted the concentrations of both IMC and SAC in solution. Actual concentration of the two components was determined using UV-Vis spectroscopy and high performance liquid chromatography (HPLC). The correlation between NIR spectra and analysis data of sampled solutions was evaluated through partial least squares (PLS) calibration model.
저자 이민정1, 천난희2, 왕인천1, 최광진2
소속 1인제대, 2순천향대
키워드 cocrystal; NIR
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