화학공학소재연구정보센터
Chemical Engineering & Technology, Vol.35, No.6, 1003-1008, 2012
Enantioselective Crystallization Exploiting the Shift of Eutectic Compositions in Solid-Liquid Phase Diagrams
Ternary solubility data of the chiral 3-chloromandelic acid (3ClMA) system are estimated for different solvents from binary solubility data using the non-random two-liquid (NRTL) model and compared to experimental data. The parameters of the NRTL model are determined by minimizing an objective function based on the difference between experimental and calculated temperatures corresponding to saturation concentrations. The results reveal that, for this system, the heterochiral interactions between the enantiomers can be considered as ideal in a wide temperature range. The ternary solubility phase diagrams are also described well by the NRTL model and predict eutectic compositions close to the enantiomer axes. Based on known ternary phase diagrams, enantiomer purification is performed experimentally, exploiting the identified shift of the characteristic eutectic compositions in the ternary phase diagram of chiral 3ClMA in different solvents.