Macromolecular Rapid Communications, Vol.32, No.19, 1533-1538, 2011
Self-Assembly Pluronic and beta-Cyclodextrin to Hollow Nanospheres for Enhanced Gene Delivery
This paper studies a kind of hollow nanospheres prepared by self-assembly beta-cyclodextrins (beta-CDs) and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (pluronic F127) for gene delivery. It was found that this kind of hollow nanospheres enable load PEI10K/DNA and the resulting F127-NH(2)-beta CD/(PEI10K/DNA) with 0.08 mu g/well DNA display equal or higher gene delivery capability compared to PEI10K/DNA with 1 mu g/well DNA in the absence or presence of serum. The cytotoxicity of the nanospheres was over 100 times lower than that of PEI10K.