Journal of the American Chemical Society, Vol.133, No.24, 9164-9167, 2011
Enantioselective Bromoaminocyclization Using Amino-Thiocarbamate Catalysts
A facile and efficient enantioselective bromoaminocyclization of unsaturated sulfonamides has been developed using an amino-thiocarbamate catalyst. A range of enantioenriched pyrrolidines were prepared with up to 99% yield and 99% ee. The corresponding lactams could be obtained through oxidation of the pyrrolidines.