화학공학소재연구정보센터
International Journal of Molecular Sciences, Vol.12, No.12, 8947-8960, 2011
The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis
The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies.