Journal of Bioscience and Bioengineering, Vol.110, No.1, 8-11, 2010
Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineering
Aspergillus oryzae penicillin biosynthetic genes were clustered. The penicillin production was positively regulated by VeA, a global gene regulator required for transcriptional expression of the penicillin biosynthetic genes. Overexpression of the biosynthetic genes by a strong promoter yielded a greater than 100-fold increase in penicillin production. (C) 2010, The Society for Biotechnology, Japan. All rights reserved.