Advanced Materials, Vol.23, No.24, H189-H194, 2011
Development of Cationic Polymer Coatings to Regulate Foreign-Body Responses
A library of cationic polymers, poly(beta-amino alcohols) with a great chemical diversity are synthesized using combinatorial polymerization. These polymers, when immobilized on a surface, drastically affect the behavior of monocyte/macrophage cells in vitro and early inflammatory reactions in vivo. Certain polymers are found capable of mitigating the foreign-body responses.