화학공학소재연구정보센터
Journal of Chemical Thermodynamics, Vol.42, No.8, 984-993, 2010
Volumetric, ultrasonic speed, and viscometric studies of salbutamol sulphate in aqueous methanol solution at different temperatures
Values of density, ultrasonic speed, and viscosity of salbutamol sulphate (SBS) have been determined in aqueous methanol solutions at T = (303.15, 308.15, 313.15, and 318.15) K. The apparent molar volume V phi, partial molar volume V phi(0) molar expansivity E-2(0), isobaric thermal expansion coefficient (alpha(2)), and second derivative of infinite dilution of partial molar volume with temperature partial derivative V-2(phi)0/partial derivative T-2 are evaluated using density data. Isentropic compressibility beta(s), change in isothermal compressibility Delta beta(s), relative change in isentropic compressibility (Delta beta/beta(0)(s)), apparent molar compressibility K-phi and partial molar compressibility K-phi(0) values are calculated by using data on density with ultrasonic speed. Viscosity B-coefficient, variation of B-coefficient with temperature, i.e., dB/dT. free energy of activation per mole of solvent Delta mu(0)(l). and solute Delta mu(0)(2). are evaluated using viscosity data. The above parameters are used to interpret the solute-solute, solute-solvent interactions and structure making/breaking ability of the drug in the given aqueous methanol solution. (C) 2010 Elsevier Ltd. All rights reserved.