화학공학소재연구정보센터
Korean Journal of Chemical Engineering, Vol.28, No.1, 239-245, January, 2011
Melt crystallization of ibuprofen on surfaces patterned by a Nd : YAG laser
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Surface-based control of melt crystallization of ibuprofen (IBU) is reported. The substrates in the present study included glass, flat Au, and laser-patterned Au. The IBU crystal morphologies were regulated depending on the surfaces where IBU crystallization was induced, and spherical, sunflower-like, and dendritic morphologies were obtained. Especially, the dendritic morphology of a large surface area was observed on the novel laser-patterned surfaces. Three-dimensionally tortuous Au structures were achieved by a 532 nm Nd : YAG laser, of which Gaussian beam profile was reshaped into a flat-top contour using a custom-designed diffusing system. Also, the effect of poly-ε-caprolactone was analyzed as a crystallization modulating additive to fine-tune the IBU crystal morphologies. The IBU crystallization behaviors as well as the laser patterning processes are described as a part of the ongoing efforts to develop a general strategy to utilize heterogeneous nucleation and directional growth to control the crystallization of important organic compounds, such as active pharmaceutical ingredients.
  1. Aizenberg J, Black AJ, Whitesides GH, J. Am. Chem. Soc., 121(18), 4500 (1999)
  2. Li M, Schnablegger H, Mann S, Nature., 402, 393 (1999)
  3. Kim IW, Robertson RE, Zand R, Adv. Mater., 15(9), 709 (2003)
  4. Mullin JW, Crystallization, Butterworth-Heinemann, Oxford (2001)
  5. Kim JH, Song SM, Kim JM, Kim WS, Kim IH, Korean J. Chem. Eng., 27(5), 1532 (2010)
  6. Weiner S, Addadi L, J. Mater. Chem., 7, 689 (1997)
  7. Mahato RI, Pharmaceutical dosage forms and drug delivery, CRC Press, Boca Raton, FL (2007)
  8. Blackstock JJ, Li ZY, Jung GY, J. Vac. Sci. Technol. A, 22(3), 602 (2004)
  9. Lee J, Park J, Hwang JH, Park S and Chung H, Proceedings of Joint International Symposia on 3rd Micro & Nano Technology and Micro/Nanoscale Energy Conversion & Transport, 143 (2010)
  10. Givargizov EI, J. Cryst. Growth, 310(7-9), 1686 (2008)
  11. Sullivan SP, Koutsonanos DG, Martin MDP, Lee JW, Zarnitsyn V, Choi SO, Murthy N, Compans RW, Skountzou I, Prausnitz MR, Nat. Med., 16, 915 (2010)