화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.394, No.3, 488-492, 2010
Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing
A wound Induces cell polarization, in which myosin II is localized at the rear end of individual cells in a migrating epithelial sheet of the Drosophila larval epidermis Here, we use myosin localization to demonstrate that Rac1, Cdc42, and Rho1 are each required for cell polarization and directional sensing of the wound The three GTPases are also required for actin cable formation at the wound leading edge Rac1, Cdc42, and Rho1 act upstream of c-Jun N-terminal kinase LINK) to organize actin assembly These results highlight the similarities between the molecular mechanism of Drosophila wound healing and those of Drosophila embryonic dorsal closure and the chemotactic response of Dictyostelium and leukocytes (C) 2010 Elsevier Inc All rights reserved