화학공학소재연구정보센터
Enzyme and Microbial Technology, Vol.45, No.2, 156-163, 2009
Lactones 32 [1] New aspects of the application of Fusarium strains to production of alkylsubstituted epsilon-lactones
Wild strains Fusarium oxysporum and Fusarium avenaceum were chosen among six to the Baeyer-Villiger oxidation of alkylsubstituted cyclohexanones (1a-e) to the corresponding highly enantiomerically enriched epsilon-lactones. Besides the oxidation activity, the biocatalysts were also able to the reduction of carbonyl group. Only cis-methylcyclohexanols turned out to be further transformed to lactones. Biotransformations of optically enriched ketones and alcohols were also studied to give an overall view of stereoselectivity of the enzymes involved in biocatalytic pathway. (C) 2009 Elsevier Inc. All rights reserved.