화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.384, No.3, 277-279, 2009
CLC-7: A potential therapeutic target for the treatment of osteoporosis and neurodegeneration
CLC-7 is a member of the voltage-gated chloride channels family. It resides mainly in the late endosomes, lysosomes and the ruffled membrane of osteoclasts. Mice deficient in the ubiquitously expressed CIC-7 Cl- channel show severe osteopetrosis and retinal degeneration. In the present review, some of the known features of CLC-7 such as structure, function and its roles in physiological or pathophysiological processes are highlighted. (C)2009 Elsevier Inc. All rights reserved.