화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.377, No.4, 1102-1106, 2008
Staphylococcus aureus surface protein SasG contributes to intercellular autoaggregation of Staphylococcus aureus
Staphylococcus aureus surface protein G (SasG) is one of cell surface proteins with cell-wall sorting motif. The sasG mutant showed significantly reduced cell aggregation and biofilm formation. SasG is comprised of variable A domain and multiple tandem repeats of B domain, native-PAGE and in vitro formaldehyde cross-linking experiments revealed that the recombinant protein of the A domain showed homo-oligomerization as an octamer, but B domain did not. This study shows that SasG-A domain contributes to intercellular autoaggregation by homo-oligomerization, and that may facilitate the adherence to host-tissues in the infection of S. aureus. (C) 2008 Elsevier Inc. All rights reserved.