화학공학소재연구정보센터
Journal of the Korean Industrial and Engineering Chemistry, Vol.19, No.6, 604-608, December, 2008
L-Ascorbic Acid의 비수계 나노 캡슐화
Nano-capsulation of L-Ascorbic Acid in Nonaqueous System
E-mail:
초록
본 연구에서는 L-아스코르빈산(L-ascorbic acid: Vitamin C)을 점성이 낮은 비수계 오일상에서의 나노 캡슐화(nano-capsulation)에 대한 기초 연구가 수행되었다. 비수계에서 제조된 나노 캡슐체들은 500 nm 이하 크기를 나타냈으며 유화물 형태에서의 평균 입자 크기는 410 nm로 나타났다. 온도와 저장 기간에 대한 안정도는 4, 20, 30 ℃ 온도에서 30일간 저장했을 때 최초 5일 후에는 5.1, 9.3, 12.5%의 L-아스코르빈산이 캡슐체로부터 유리되어 나왔으나 이후 기간 동안에는 약 1∼2% 정도가 유리되어 나왔다. 또한, 남녀 각각 10명의 대상인원에 대한 피부 자극도는 1명만이 2일 후에 아주 미세한 피부 자극이 나타났으며 다른 인원에게서는 무자극성을 나타내었다.
In this work, the basic research for nano-capsulation of L-ascorbic acid (Vitamin C) in nonaqueous system was carried out. 500 nm-sized nano-capsules were prepared in nonaqueous system, and the emulsified capsule had mean size of 410 nm. The stability test on the temperature and the storage periods was performed at 4, 20, and 30 ℃ for 30 days. After 5 days, L-ascorbic acid was extricated 5.1, 9.3, and 12.5% at each temperature, but only 1∼2 % was extricated after the time span. Likewise, the results of the skin susceptibility on women and men, each 10 persons, revealed that the very thin allergy was shown from only a woman after 2 days, but it was not shown from the others.
  1. Shahidi F, Han XQ, Critical Reviews in Food Science and Nutrition, 33, 501 (1993)
  2. Pothakamury UR, Barbosa-Canovas GV, Trends in Food Science & Technology, 6, 397 (1995)
  3. Dziezak JD, Food Technology, 52, 136 (1998)
  4. Pszczola DE, Food Technology, 52, 70 (1998)
  5. Kanawjia SK, Pathania V, Singh S, Indian Dairyman, 44, 280 (1992)
  6. Fanger GO, Microcapsulation processes and application, Plenum press, NY, (1974)
  7. Deasy PB, Microencapsulation and related drug processes, Marcel Dekker. Inc., NY, (1984)
  8. USP 2, 556, 410 (1951)
  9. Ahn BY, Kim JH, Seok SI, Ko SY, Chang HK, J. Korean Ind. Eng. Chem., 13(7), 672 (2002)
  10. Machlin LJ, Handbook of Vitamins, 2nd Ed, Marcel Dekker, Inc., NY, (1991)
  11. Doba T, Burton GW, Ingold KU, Biochim. Biophys. Acta, 835, 298 (1985)
  12. Bossi A, Piletsky SA, Piletska EV, Righetti PG, Turner A, Anal Chem., 2, 4296 (2007)
  13. Yamamoto L, Tai A, Fujinami Y, Sasaki K, Okazaki K, Okazaki SJ, Med. Chem., 45, 462 (2002)
  14. Tsuchiya H, Bates CJ, J. Nurt. Biochem., 9, 402 (1998)
  15. Horino Y, Takahashi S, Miura T, Takahashi Y, Life Science, 71, 3031 (2002)
  16. Goodman LS, Gilman A, As Bases Farmacologicas da Terapeutica, 9th Ed., McGraw Hill, (1996)
  17. Hamilton IMJ, Gilmore WS, Benzie IFF, Mulholland CW, Strain JJ, British Journal of Nutrition, 84, 261 (2000)
  18. USP 5, 286, 495 (1994)