화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.301, No.3, 641-645, 2003
Fission yeast synaptobrevin is involved in cytokinesis and cell elongation
Synaptobrevin is a vesicle-associated membrane protein playing an essential role in regulated vesicle transport. In this study, we characterized Syb1, synaptobrevin of Schizosaccharomyces pombe. Syb1 was located on various sizes of vesicle-like structures in the cytoplasm and enriched in the medial region and cell ends. Transport of Syb1 to the medial region was mainly dependent on F-actin and Myo52/Myo4. Syb1 is essential for cell viability and most of the syb1-null cells showed a round or short cylindrical form. These results suggest that Syb1 is involved in membrane trafficking of cytokinesis and cell elongation. (C) 2003 Elsevier Science (USA). All rights reserved.