화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.268, No.1, 133-135, 2000
Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site
A series of inhibitors of beta-amyloid formation have been developed based on the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein. A simple tripeptide aldehyde was found to be the most potent (IC50 = 700 nM) in the series displaying an inhibitory profile which is different from reported inhibitors of beta-amyloid formation.