Biochemical and Biophysical Research Communications, Vol.350, No.2, 315-321, 2006
Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation
Epidermal growth factor (EGF) and ErbB family molecules play a role in heart development and function. To investigate the role of EGF family member, heparin-binding EGF-like growth factor (HB-EGF) in heart development, smooth muscle and endothelial cell lineage-specific HB-EGF knockout mice were generated using the Cre/loxP system in combination with the SM22 alpha or TIE2 promoter. HBEGF knockout mice displayed enlarged heart valves, and over half of these mice died during the first postnatal week, while survivors showed cardiac hypertrophy. These results suggest that expression of HB-EGF in smooth muscle and/or endothelial cell lineages is essential for proper heart development and function in mice. (c) 2006 Elsevier Inc. All rights reserved.