화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.334, No.2, 313-318, 2005
Curcumin inhibits interferon-alpha induced NF-kappa B and COX-2 in human A549 non-small cell lung cancer cells
The A549 cells, non-small cell lung cancer cell line from human,were resistant to interferon (IFN)-alpha treatment. The IFN-alpha-treated A549 cells showed increase in protein expression levels of NF-kappa B and COX-2. IFN-alpha induced NF-kappa B binding activity within 30 min and this increased binding activity was markedly suppressed with inclusion of curcurnin. Curcumin also inhibited IFN-alpha-induced COX-2 expression in A549 cells. Within 10 min, IFN-alpha rapidly induced the binding activity of a gamma-(32) P-labeled consensus GAS oligonucleoticle probe, which was profoundly reversed by curcumin. Taken together, IFN-alpha-induced activations of NF-kappa B and COX-2 were inhibited by the addition of curcumin in A549 cells. (c) 2005 Elsevier Inc. All rights reserved.