화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.319, No.1, 27-31, 2004
Determination of amino acid pairs sensitive to variants in human copper-transporting ATPase 2
In this study, we use our probabilistic approach to analyze the amino acid pairs in human copper-transporting ATPase 2 (ATP7B) in order to determine which amino acid pairs are more sensitive to 125 variants from missense mutant human ATP7B. The results show 97.6% of 125 variants occur at randomly unpredictable amino acid pairs, which account for 80.9% of amino acid pairs in ATP7B, and the chance of occurring of variant is about 9 times higher in randomly unpredictable amino acid pairs than in predictable pairs. Thus, the randomly unpredictable amino acid pairs are more sensitive to variants in human ATP7B. (C) 2004 Elsevier Inc. All rights reserved.