화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.316, No.1, 12-17, 2004
CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression
CD43 is a transmembrane molecule with a highly O-glycosylated extracellular domain of mucin type. It is a normal constituent of leukocytes and found in colon adenoma, but not in normal colon epithelia. Here it is shown that the cytoplasmic tail of CD43 contains a functional bipartite nuclear localization signal directing it to the nucleus. The intracellular domain of CD43 interacts with beta-catenin and causes an upregulation of the beta-catenin target genes c-MYC and CyclinD1. The present results suggest that CD43 can be involved in nuclear signaling and via beta-catenin interaction be involved in cell proliferation. (C) 2004 Elsevier Inc. All rights reserved.