화학공학소재연구정보센터
Chemistry Letters, Vol.34, No.10, 1330-1331, 2005
A new one-pot synthesis of thiocarbamates from isocyanates and disulfides in the presence of Zn/AlCl3 system
A novel method has been developed for the synthesis of S-alkyl(aryl) thiocarbamates. The route involves, first, the formation of zinc thiolates by reductive cleavage of disulfides in the presence of Zn/AlCl3 system; then subsequent reaction of the thiolate anions with isocyanates gives the desired thiocarbamates in high to excellent yields.