Inorganic Chemistry, Vol.45, No.19, 7815-7820, 2006
Polyester-based carborane-containing dendrons
New carborane-containing dendrons based on a 2,2-bis(hydroxymethyl) propanoic acid scaffold have been prepared for applications in boron neutron capture therapy. A generation-2 carborane-containing dendron carrying 40 boron atoms was the highest generation synthetically available due to the steric crowding. The structure of this dendron has been simulated by molecular dynamics. A 10-carbon linker carrying a carboxylic group has been installed at the focal point of the dendron to distance the attachment point from the sterically hindered core.