화학공학소재연구정보센터
Macromolecular Research, Vol.14, No.1, 73-80, February, 2006
Surface Modification of Polyurethane Using Sulfonated PEG Grafted Polyrotaxane for Improved Biocompatibility
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Sulfonated poly(ethylene glycol) (PEG-SO3) grafted polyrotaxanes (PRx-PEG-SO3) were prepared in order to utilize the unique properties of PEG-SO3 and the supramolecular structure of PRx, in which PEG-SO3 grafted α-cyclodextrins ( α-CDs) were threaded onto PEG segments in a PEG-b-poly(propylene glycol) (PPG)-b-PEG triblock copolymer (Pluronic) chain capped with bulky end groups. Some of the PRx-PEG-SO3 demonstrated a higher anticoagulant activity in case of PRx-PEG-SO3 (P105), and compared with the control they showed a lower fibrinogen adsorption in PRx-PEG-SO3 (F68) and a higher binding affinity with fibroblast growth factor. The obtained results suggested that polyrotaxane incorporated with PEG-SO3 may be applicable to the surface modification of clinically used polymers, especially for blood/cell compatible medical devices.
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