화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.127, No.41, 14473-14478, 2005
Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: Insights into nonfouling properties of zwitterionic materials
In this work, we show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMS) to protein adsorption and examine key factors leading to their nonfouling behavior using both experimental and molecular simulation techniques. Zwitterions with a balanced charge and minimized dipole are excellent candidates as nonfouling materials due to their strong hydration capacity via electrostatic interactions.