화학공학소재연구정보센터
Chemical Engineering & Technology, Vol.21, No.4, 354-356, 1998
Improving microbial productivity through dialytic reclamation of inhibitory acids: The Propioni system
The production of vitamin B-12 via fermentation is inhibited by the coproduct propionic acid. Removal of the acid from the active fermenter by neutralization dialysis is achieved by counter exchange of acid anions and hydroxyl ions through anion exchange membranes Reported are the results from fed-batch fermentation and the improved yield and productivity for both biomass and propionic acid.