화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.125, No.50, 15433-15442, 2003
Total synthesis of apoptolidin: Construction of enantiomerically pure fragments
A general strategy for the total synthesis of the antitumor agent apoptoliclin (1) is proposed, and the chemical synthesis of the defined key building blocks (4, 5, 6, 8, and 9) in their enantiomerically pure forms is described. The projected total synthesis calls for a dithiane coupling reaction to Construct the C-20-C-21 bond, a Stille coupling reaction to form the C-11-C-12 bond, and a Yamaguchi macrolactonization to assemble the macrolide ring, as well as two glycosidation reactions to fuse the carbohydrate units onto the molecule. First and second generation syntheses to the required fragments for apoptoliclin (1) are described.