화학공학소재연구정보센터
Science, Vol.273, No.5271, 70-74, 1996
The Aging Immune-System - Primer and Prospectus
Changes in T lymphocyte populations underlie much of the age related decline in the protective immune response. Aging leads to the replacement of virgin T cells by memory T cells and to the accumuiation of cells with signal transduction defects. Studies of antibody gene assembly, accessory cell function, post-thymic T cell development, skewed selection of T cell receptor repertoire, and the clinical concomitants of immune senescence will shed new light on the causes and consequences of age-dependent immune failure.