화학공학소재연구정보센터
Applied Chemistry for Engineering, Vol.34, No.2, 186-191, April, 2023
Promotion of 3T3 and HDF Cell Migration by Gelatin-modified Fibroin Microspheres
The goal of this study was to use gelatin to modify the surface of fibroin microspheres to enhance their biofunctionality for tissue engineering and regenerative medicine applications. Three different methods were used for the modification: coating, incorporation, and covalent bonding. Wound-healing assays demonstrated that gelatin modification of fibroin microspheres en hances 3T3 and HDF cell migration. Although the level of gelatin coverage varied depending on the method used, there was no significant difference between the modified microspheres. The gelatin-modified microspheres also increased the migration velocity of individual 3T3 cells. The results suggest that gelatin modification of fibroin microspheres is a promising approach for developing functional biomaterials with enhanced biological properties. Further optimization of gelatin modification is nec essary to maximize the biofunctionality of fibroin microspheres.