화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.46, No.6, 837-842, November, 2022
DOI10.7317/pk.2022.46.6.837  Export Citation
전기방사법으로 제조한 PCL/젤라틴/셀룰로오스 지지체의 기계적 특성 및 생체적합성
Mechanical Properties and Biocompatibility of Electrospun Poly(-caprolactone)/Gelatin Scaffolds Loaded with Cellulose Fiber
정유정, 이득용†
  • 대림대학교 보건의료공학과
Yujeong Jeong, and Deuk Yong Lee†
  • Department of Biomedical Engineering, Daelim University, Anyang 13916, Korea
E-mail:
초록
18 wt% PCL/젤라틴(P/g)에 셀룰로오스 섬유(CF)를 첨가하여 P/g/CF 지지체를 전기방사하고, CF 농도에 따른 인장강도, 투습도, 수분흡수도, 세포독성 및 증식 특성을 조사하였다. CF 농도가 0에서 4 wt%로 증가함에 따라, 점도는 811에서 1121 cP로 증가하였고 섬유 직경은 462에서 869 nm로 증가하였다. 2 wt% CF가 첨가된 P/g/CF에서 4.8±0.8 MPa 최대 인장강도값이 관찰되었지만, CF 농도가 증가함에 따라 강도값은 감소하였다. FTIR 결과, CF농도가 증가함에 따라 지지체 내부의 CF와 젤라틴 간의 수소결합에 의하여 PCL 결정도가 감소하였다. 최적의 투습도와 물 흡수도는 CF농도가 각각 1%와 2%일 때 관찰되었다. 세포생존률과 세포 증식은 CF농도에 상관없이 P/g/CF지지체 에서 유사하였다. 실험결과, 상처드레싱재로 적합한 최적의 특성을 가진 지지체는 CF농도가 2 wt%인 P/g/CF에서 관찰되었다.
The cellulose fiber (CF)-loaded PCL/gelatin (P/g) scaffolds were electrospun to investigate the effect of CF content on the strength, moisture vapor transmission rate (MVTR), water uptake capacity (WUC), and cytotoxicity of the P/g/CF scaffolds. The fiber diameter gradually increased from 462 to 869 nm with increasing the CF content from 0 to 4 wt% due to the increase in viscosity from 811 to 1121 cP. The strength increased from 2.2±0.3 to 4.8±0.8 MPa as the CF content increased from 0 to 2 wt%, and decreased with additional CF doping. FTIR results revealed that PCL crystallinity decreased with increasing CF content due to H bonds between cellulose and gelatin. The highest MVTR (CF=1 wt%) and WUC (CF=2 wt%) values are observed. Excellent cell viability and proliferation were observed in P/g/CF scaffolds regardless of CF content. It can be concluded that P/g scaffolds loaded with 2% CF are highly suitable as wound dressings.
Keywords:poly(ε-caprolactone);gelatin;cellulose fiber;electrospinning;scaffold;wound dressing
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