화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.30, No.6, 397-405, June, 2022
DOI10.1007/s13233-022-0049-1  Export Citation
Development of Gelatin Thin Film Reinforced by Modified Gellan Gum and Naringenin-Loaded Zein Nanoparticle as a Wound Dressing
Marjan Ghorbani†, Nasrin Hassani1, and Mortaza Raeisi2
  • Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • 1Department of Biology, Islamic Azad University, Shiraz, Iran
  • 2Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
E-mail:
Today, the importance of biocompatible nanocomposite films with suitable properties for potential applications in wound healing has been considered. In present study, nanocomposite films of gelatin/aldehyde-gellan gum/Naringenin-loaded Zein nanoparticle (GL/AG/NR@Z) were successfully produced with the solution casting method. NR@Z with different concentrations (1.5 and 3 wt%) loaded into the GL/AG films. Then, the morphological, structural, thermal, and physical properties of these films were investigated. The obtained findings illustrated that by addition of NR@Z content a denser and more porous structure with high swelling ratio (around 80%), high thermal stability, high tensile stress (54.33 ± 3.45 MPa), and high weight loss (around 70%) was observed. Cell viability assessment of the produced films displayed no cytotoxicity for NIH3T3 fibroblast cells. Furthermore, since NR is a polyphenolic compound, the produced GL/AG/NR@Z nanocomposite films showed antioxidant and antibacterial activity. Consequently, we demonstrated that nanocomposite films (GL/AG/NR@Z) could be a suitable scaffold for wound healing applications.
Keywords:gelatin;aldehyde gellan gum;naringenin;zein nanoparticle;nanocomposite film;wound healing
  1. Qu J, Zhao X, Liang Y, Zhang T, Ma PX, Guo B, Biomaterials, 183 (2018)
  2. Kamoun EA, Kenawy ERS, Chen X, J. Adv. Res., 8, 217 (2017)
  3. Muchová M, Münster L, Capáková Z, Mikulcová V, Kuřitka I, Vícha J, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 116, 111242 (2020)
  4. Kim SE, Heo DN, Lee JB, Kim JR, Park SH, Jeon SH, Kwon IK, Biomed. Mater., 4, 044106 (2009)
  5. Almasian A, Najafi F, Eftekhari M, Ardekani MRS, Sharifzadeh M, Khanavi M, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 114, 111039 (2020)
  6. Qu J, Zhao X, Liang Y, Xu Y, Ma PX, Guo B, Chem. Eng. J., 362, 548 (2019)
  7. Hamedi H, Moradi S, Hudson SM, Tonelli AE, Carbohydr. Polym., 199, 445 (2018)
  8. Güldiken CG, Karaosmanoğlu O, Sivas H, Gerçel HF, J. Appl. Polym. Sci., 137, 1 (2020)
  9. Kaczmarek B, Nadolna K, Owczarek A, Michalska-Sionkowska M, Sionkowska A, Polym. Test, 78, 106007 (2019)
  10. Mohebian Z, Maroufi LY, Ghorbani M, New J. Chem., 45, 13814 (2021)
  11. Wang L, Lin L, Guo Y, Long J, Mu RJ, Pang J, Food Hydrocolloids, 108, 105863 (2020)
  12. Shankar S, Wang LF, Rhim JW, Food Packag. Shelf Life, 21, 100363 (2019)
  13. Patel S, Srivastava S, Singh MR, Singh D, Int. J. Biol. Macromol., 107, 1888 (2018)
  14. Hubner P, Donati N, de M. Quines LK, Tessaro IC, Marcilio NR, Mater. Sci. Eng. C-Biomimetic Supramol. Syst. (2020)
  15. Kavoosi G, Dadfar SMM, Purfard AM, J. Food Sci., 78, 244 (2013)
  16. Akrami-Hasan-Kohal M, Ghorbani M, Mahmoodzadeh F, Nikzad B, Int. J. Biol. Macromol., 160, 669 (2020)
  17. Chetouani A, Elkolli M, Bounekhel M, Benachour D, Polym. Bull., 71, 2303 (2014)
  18. Ghorbani M, Roshangar L, Soleimani J, Eur. Polym. J., 130, 109697 (2020)
  19. Ismail NA, Amin KAM, Majid FAA, Razali MH, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 103, 109770 (2019)
  20. Zhang X, Pan Y, Li S, Xing L, Du S, Yuan G, Li J, Zhou T, Xiong D, Tan H, Ling Z, Chen Y, Hu X, Niu X, Int. J. Biol. Macromol., 164, 2204 (2020)
  21. Gomes ED, Mendes SS, Leite-Almeida H, Gimble JM, Tam RY, Shoichet MS, Sousa N, Silva NA, Salgado AJ, Biomaterials, 105, 38 (2016)
  22. Wang P, Luo Z, Xiao Z, Carbohydr. Polym., 260, 117794 (2021)
  23. Jelkmann M, Leichner C, Zaichik S, Laffleur F, Bernkop-Schnürch A, Int. J. Biol. Macromol., 158, 1037 (2020)
  24. Maheswary T, Nurul AA, Fauzi MB, Pharmaceutics, 13, 981 (2021)
  25. Homaeigohar S, Boccaccini AR, Acta Biomater., 107, 25 (2020)
  26. Zeng W, Jin L, Zhang F, Zhang C, Liang W, Pharmacol. Res., 135, 122 (2018)
  27. Wang Y, Wang S, Firempong CK, Zhang H, Wang M, Zhang Y, Zhu Y, Yu J, Xu X, AAPS PharmSciTech, 18, 586 (2017)
  28. Kumar SP, Birundha K, Kaveri K, Devi KTR, Int. J. Biol. Macromol., 78, 87 (2015)
  29. Fan H, Zhang P, Zhou L, Mo F, Jin Z, Ma J, Lin R, Liu Y, Zhang J, Pharm. Dev. Technol., 25, 547 (2020)
  30. Ebrahimi MH, Samadian H, Davani ST, Kolarijani NR, Mogharabian N, Salami MS, Salehi M, J. Mol. Liq., 318, 114226 (2020)
  31. Md S, Alhakamy NA, Aldawsari HM, Asfour HZ, Brain Sci., 9, 275 (2019)
  32. Zhang P, Liu X, Hu W, Bai Y, Zhang L, Carbohydr. Polym., 149, 224 (2016)
  33. Park SH, Shin HS, Park SN, Carbohydr. Polym., 200, 341 (2018)
  34. Yavari L, Ghorbani M, Tabibiazar M, Mohammadi M, Pezeshki A, Advanced Properties of Gelatin Fi Lm by Incorporating Modi Fi Ed Kappa-Carrageenan and Zein Nanoparticles for Active Food Packaging., 183, 753 (2021).
  35. Kasaai MR, Trends Food Sci. Technol., 79, 184 (2018)
  36. Luo Y, Wang Q, J. Appl. Polym. Sci., 131, 40696 (2014)
  37. Liu Q, Jing Y, Han C, Zhang H, Tian Y, Food Hydrocolloids, 93, 432 (2019)
  38. Yavari L, Ghorbani M, International Journal of Biological Macromolecules Injectable Chitosan-Quince Seed Gum Hydrogels Encapsulated with Curcumin Loaded-Halloysite Nanotubes Designed for Tissue Engineering Application., 177, 485 (2021).
  39. Mohammadi MA, Ramezani S, Hosseini H, Mortazavian AM, Hosseini SM, Ghorbani M, Food Bioprocess Technol., 14, 1529 (2021)
  40. Ghorbani M, Mahmoodzadeh F, Maroufi LY, Nezhad-Mokhtari P, Int. J. Biol. Macromol., 165, 1312 (2020)
  41. Siripatrawan U, Harte BR, Food Hydrocolloids, 24, 770 (2010)
  42. Raeisi S, Chavoshi H, Mohammadi M, Ghorbani M, Sabzichi M, Ramezani F, Process Biochem., 83, 168 (2019)
  43. Maroufi LY, Ghorbani M, Tabibiazar M, Food Bioprocess Technol., 13, 1633 (2020)
  44. Khodaei D, Oltrogge K, Hamidi-Esfahani Z, Lwt, 117, 108617 (2020)
  45. Lee H, You J, Jin HJ, Kwak HW, Carbohydr. Polym., 232, 115771 (2020)
  46. Okur ME, Sakul AA, Ayla S, Karadag AE, Senyüz CS, Batur S, Daylan B, Özdemir EM, Palabiyik-YücelIk S, SIpahl H, Aydin A, Ankara Univ. Eczac. Fak. Derg., 44, 397 (2020)
  47. Farajpour R, Djomeh ZE, Moeini S, Tavahkolipour H, Safayan S, Int. J. Biol. Macromol., 149, 941 (2020)
  48. Luo Y, Teng Z, J. Agric. Food Chem., 60, 836 (2012)
  49. Smruthi MR, Nallamuthu I, Anand T, Food Chem., 369, 130950 (2022)
  50. Rhim J, Park H, Ha C, Prog. Polym. Sci., 38, 1629 (2013)
  51. Cui H, Surendhiran D, Li C, Lin L, Food Packag. Shelf Life, 24, 100511 (2020)
  52. Liu Y, Deng L, Zhang C, Feng F, Zhang H, J. Agric. Food Chem., 66, 1907 (2018)
  53. Mu C, Guo J, Li X, Lin W, Li D, Food Hydrocolloids, 27, 22 (2012)
  54. Spasojević L, Katona J, Bučko S, Savić SM, Petrović L, Budinčić JM, Tasić N, Aidarova S, Sharipova A, LWT — Food Sci. Technol., 109, 350 (2019)
  55. Oymaci P, Altinkaya SA, Food Hydrocolloids, 54, 1 (2016)
  56. Kerdudo A, Dingas A, Fernandez X, Faure C, Food Chem., 159, 12 (2014)
  57. Jabbari M, Jabbari A, Colloids Surf. A: Physicochem. Eng. Asp., 489, 392 (2016)
  58. Kim H, In H, Park S, Kim K, Hoon T, Choe W, Jo C, Food Chem., 160, 241 (2014)
  59. Gerçek E, Zengin H, Erişir FE, Yilmaz O, Comp. Biochem. Physiol. C: Toxicol. Pharmacol., 241, 108969 (2021)
  60. Kumar SP, Birundha K, Kaveri K, Devi KTR, Int. J. Biol. Macromol., 78, 87 (2017)
  61. Mundlia J, Ahuja M, Kumar P, Pillay V, 3 Biotech, 9, 312 (2019)
  62. Patel K, Singh GK, Patel DK, Chin. J. Integr. Med., 24, 551 (2018)
  63. Agus S, Achmadi SS, Mubarik NR, Asian Pac. J. Trop. Biomed., 7, 725 (2017)
  64. Maji K, Dasgupta S, Pramanik K, Bissoyi A, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 86, 83 (2018)
  65. Hatkevich T, Ramos J, Santos-sanchez I, Patel YM, Exp. Cell Res., 327, 331 (2014)
  66. Frydoonfar HR, Mcgrath DR, Spigelman AD, Colorectal Dis., 5, 149 (2003)
  67. Salehi B, Valere P, Fokou T, Sharifi-rad M, Zucca P, Pezzani R, Sharifi-rad J, A Review of Clinical Trials., 26, 1 (2019)
  68. Sargazi ML, Juybari KB, Tarzi ME, Amirkhosravi A, Nematollahi MH, Mirzamohammdi S, Mehrbani M, Mehlabani M, Mehrabani M, Mol. Biol. Rep., 48, 6413 (2021)
  69. Srivastava CM, Purwar R, Kannaujia R, Sharma D, Fibers Polym., 16, 1020 (2015)
  70. Niculescu AG, Grumezescu AM, Polymer, 14, 421 (2022)