Three different rubbers, hydrogenated nitrile butadiene rubber (HNBR), ethylene vinyl acetate copolymer (EVM) and ethylene propylene diene rubber (EPDM), and two blends, HNBR/EVM and HNBR/EPDM were compounded both with and without fillers, and were vulcanized with the same peroxide curing system. Peppas- Sahlin model was used to explain the diffusion mechanism of solvents in rubber vulcanizates. Transport parameters including diffusion coefficient, sorption coefficient and permeation coefficient were calculated and correlated with Flory-Huggins interaction parameters (χ). The Peppas-Sahlin model dealing with diffusion behaviors of solvents shows high degree of fitting for both unfilled and filled rubber-solvent systems. With the addition of carbon black, the diffusion coefficient increases while the sorption and permeation coefficients decrease. The sorption coefficient increases linearly with the permeation coefficient. New Flory-Huggins interaction parameter (χN) calculated by threedimensional solubility parameters shows better predictive power in diffusion behaviors than the traditional one (χT). By mathematical fitting, a linear relationship can be obtained between the maximum swelling ratio and χN, while an exponential relationship is gained for the permeation coefficient. The discovery of this rule connects three-dimensional solubility parameters with the swelling of polymer in solvent, which provides experimental basis for the further study of the medium resistance of polymer.