화학공학소재연구정보센터
Applied Chemistry for Engineering, Vol.33, No.1, 17-27, February, 2022
근적외선-II 형광 이미징을 위한 무기 나노입자
Inorganic Nanoparticles for Near-infrared-II Fluorescence Imaging
E-mail:
초록
형광 이미징은 시간 분해능과 공간 해상도가 높기 때문에 기초연구에서 세포나 소동물 이미징에 널리 활용된다. 기존의 형광 이미징은 가시광선 영역의 광원을 활용하기 때문에 조직 내 광투과도가 낮고, 광원에 의한 광독성이 생길 수 있으며, 자가형광에 의한 간섭으로 검출 민감도가 떨어지는 한계가 있다. 이러한 점을 개선하기 위해 에너지가 낮은 장파장의 광원을 활용하고자 하며, 700~900 nm 영역을 활용하는 근적외선-I 형광 이미징이 개발되었고, 이미징성능을 대폭 향상시키기 위해서 1000~1700 nm 영역의 장파장을 이용하는 근적외선-II 이미징이 연구자들의 관심을 받고 있다. 근적외선-II 영역은 광산란이 최소화되어 생체조직 내 투과도를 약 10 mm까지 향상시킬 수 있고, 생체조직의 자가형광도 최소화되어 고민감도와 고해상도의 형광 이미징이 가능하다. 본 총설에서는 다양한 근적외선-II 형광 이미징 탐침 중에서 광안정성이 뛰어나고 발광 파장 조절이 용이한 무기 나노입자 기반 탐침에 대해 살펴보았고, 그 중에서 단층 탄소 나노튜브와 양자점 및 란탄족 나노입자에 대해 중점적으로 기술하였다.
Fluorescence imaging is widely used to image cells or small animals due to its high temporal and spatial resolution. Because conventional fluorescence imaging uses visible light, the penetration depth of light within the tissue is low, phototoxicity may occur due to visible light, and the detection sensitivity is lowered due to interference by background autofluorescence. In order to overcome this limitation, long-wavelength light should be used, and fluorescence imaging using near-infrared-I (NIR-I) in the region of 700~900 nm has been developed. To further improve imaging quality, researchers are interested in using a longer wavelength light, near-infrared-II (NIR-II) ranging from 1000 to 1700 nm. In the NIR-II region, light scattering is further minimized, and the penetration depth of light in the tissue is improved up to about 10 mm, and autofluorescence of the tissue is reduced, enabling high sensitivity and resolution fluorescence imaging. In this review, among various NIR-II fluorescence imaging probes, inorganic nanoparticle-based probes with excellent photostability and easily tunable emission wavelength were described, focusing on single-walled carbon nanotubes, quantum dots, and lanthanide nanoparticles.
  1. Kim D, KimJ, Park YI, Lee N, Hyeon T, ACS Central Sci., 4, 324 (2018)
  2. Hong G, Antaris AL, Dai H, Nat. Biomed. Eng., 1, 0010 (2017)
  3. Ding F, Fan Y, Sun Y, Zhang F, Adv. Healthcare Mater., 8, 190026 (2019)
  4. Ren F, Jiang Z, Han M, Zhang H, Yun B, Zhu H, Li Z, View, 2, 202001 (2021)
  5. Ding F, Zhan Y, Lu X, Sun Y, Chem. Sci., 9, 4370 (2018)
  6. Kim D, Lee N, Park YI, Hyeon T, Bioconjugate Chem., 28, 115 (2017)
  7. Welsher K, Sherlock SP, Dai H, Proc. Natl. Acad. Sci. U. S. A., 108, 8943 (2011)
  8. Diao S, Blackburn JL, Hong G, Antaris AL, Chang J, Wu JZ, Zhang B, Cheng K, Kuo CJ, Dai H, Angew. Chem.-Int. Edit., 54, 14758 (2015)
  9. Dang X, Gu L, Qi J, Correa S, Zhang G, Belcher AM, Hammond PT, Proc. Natl. Acad. Sci. U. S. A., 113, 5179 (2016)
  10. Lin CW, Yang H, Sanchez SR, Mao W, Pang L, Beckingham KM, Bast RC, Weisman RB, ACS Appl. Mater. Interfaces, 9, 41680 (2017)
  11. Yang HY, Zhao YW, Zhang ZY, Xiong HM, Yu SN, Nanotechnology, 24, 055706 (2013)
  12. Chen GC, Tian F, Zhang Y, Zhang YJ, Li CY, Wang QB, Adv. Funct. Mater., 24(17), 2481 (2014)
  13. Santos HDA, Gutierrez IZ, Shen YL, et al., Nat. Commun., 11, 12 (2020)
  14. Kong Y, Chen J, Fang H, Heath G, Wo Y, Wang W, Li Y, Guo Y, Evans SD, Chen S, Zhou D, Chem. Mater., 28, 3041 (2016)
  15. Huang B, Hu J, Li H, Luo MY, Chen S, Zhang M, Sun ZJ, Cui R, ACS Appl. Bio Mater., 3, 1636 (2020)
  16. Chen M, Feng S, Yang Y, Li Y, Zhang J, Chen S, Chen J, Nano Res., 13, 3123 (2020)
  17. Yang X, Wang Z, Huang H, Ling S, Zhang R, Zhang Y, Chen G, Li C, Wang Q, Adv. Healthcare Mater., 10, 200154 (2021)
  18. Bruns OT, Bischof TS, Harris DK, et al., Nat. Biomed. Eng., 1, 0056 (2017)
  19. Hao X, Li C, Zhang Y, Wang H, Chen G, Wang M, Wang Q, Adv. Mater., 30, 180443 (2018)
  20. Zhang Y, Yang H, An X, Wang Z, Yang X, Yu M, Zhang R, Sun Z, Wang Q, Small, 16, 200100 (2020)
  21. Sarkar S, Le P, Geng JL, Liu Y, Han ZY, Zahid MU, Nall D, Youn Y, Selvin PR, Smith AM, J. Am. Chem. Soc., 142(7), 3449 (2020)
  22. Tao ZM, Dang XN, Huang X, et al., Biomaterials, 134, 202 (2017)
  23. Liu YX, Fan HM, Guo QW, Jiang AQ, Du XX, Zhou J, Theranostics, 7, 4217 (2017)
  24. Yang QH, Li XL, Xue ZL, Li YB, Jiang MY, Zeng SJ, RSC Adv., 8, 12832 (2018)
  25. Li X, Jiang M, Li Y, Xue Z, Zeng S, Liu H, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 100, 260 (2019)
  26. He S, Song J, Liu J, Liu L, Qu J, Cheng Z, Adv. Opt. Mater., 7, 190004 (2019)
  27. Cheng S, Liu L, Yang Q, Li Y, Zeng S, J. Rare Earths, 37, 931 (2019)
  28. Zhao M, Li B, Wu Y, He H, Zhu X, Zhang H, Dou C, Feng L, Fan Y, Zhang F, Adv. Mater., 32, 200117 (2020)
  29. Wu L, Hu J, Zhou Q, Lin Y, Huang D, Chen D, Lu H, Zhu H, Nanoscale, 12, 14180 (2020)
  30. Jiang MY, Liu HR, Zeng SJ, Hao JH, Adv. Ther., 2, 10 (2019)
  31. Li H, Wang X, Li X, Zeng S, Chen G, Chem. Mater., 32, 3365 (2020)
  32. Lv R, Wang Y, Lin B, Peng X, Liu J, Lu W, Tian J, Anal. Chem., 93, 4984 (2021)
  33. Kantamneni H, Barkund S, Donzanti M, et al., BMC Cancer, 20, 1082 (2020)
  34. Wang C, Lin H, Ge X, Mu J, Su L, Zhang X, Niu M, Yang H, Song J, Adv. Funct. Mater., 31, 200994 (2021)
  35. Yu Z, Musnier B, Wegner KD, et al., ACS Nano, 14, 4973 (2020)
  36. Tsuboi S, Jin T, ECS J. Solid State Sci. Technol., 10, 096012 (2021)
  37. Jiang Y, Li J, Zhen X, Xie C, Pu K, Adv. Mater., 30, 170598 (2018)
  38. Dai Y, Zhao H, He K, Du W, Kong Y, Wang Z, Li M, Shen Q, Sun P, Fan Q, Small, 17, 210252 (2021)
  39. Jiang Y, Upputuri PK, Xie C, et al., Adv. Mater., 31, 180816 (2019)
  40. Shou K, Tang Y, Chen H, Chen S, Zhang L, zhang A, Fan Q, Yu A, Cheng Z, Chem. Sci., 9, 3105 (2018)
  41. Yang Y, Chen J, Yang Y, Xie Z, Song L, Zhang P, Liu C, Liu J, Nanoscale, 11, 7754 (2019)
  42. Zhang W, Sun X, Huang T, Pan X, Sun P, Li J, Zhang H, Lu X, Fan Q, Huang W, Chem. Commun., 55, 9487 (2019)
  43. Zhang Z, Fang X, Liu Z, Liu H, Chen D, He S, Zheng J, Yang B, Qin W, Zhang X, Wu C, Angew. Chem.-Int. Edit., 59, 3691 (2020)
  44. Chen H, Shou K, Chen S, et al., Adv. Mater., 33, 200690 (2021)
  45. Qi J, Alifu N, Zebibula A, Wei P, Lam JWY, Peng HQ, Kwok RTK, Qian J, Tang BZ, Nano Today, 34, 100893 (2020)
  46. Qin W, Alifu N, Lam JWY, Cui Y, Su H, Liang G, Qian J, Tang BZ, Adv. Mater., 32, 200036 (2020)
  47. Li S, Deng Q, Zhang Y, Li X, Wen G, Cui X, Wan Y, Huang Y, Chen J, Liu Z, Wang L, Lee CS, Adv. Mater., 32, 200114 (2020)
  48. Zhang W, Deng W, Zhang H, Sun X, Huang T, Wang W, Sun P, Fan Q, Huang W, Biomaterials, 243, 119934 (2020)
  49. Zhang Z, Xu W, Kang M, Wen H, Guo H, Zhang P, Xi L, Li K, Wang L, Wang D, Tang BZ, Adv. Mater., 32, 200321 (2020)
  50. Ding F, Chen Z, Kimi WY, Sharma A, Li C, Ouyang Q, Zhu H, Yang G, Sun Y, Kim JS, Chem. Sci., 10, 7023 (2019)
  51. Li L, Shao C, Liu T, et al., Adv. Mater., 32, 200347 (2020)
  52. Li T, Liu L, Xu P, Yuan P, Tian Y, Cheng Q, Yan L, Adv. Ther., 4, 200024 (2021)
  53. Tang Y, Li Y, Hu X, Zhao H, Ji Y, Chen L, Hu W, Zhang W, Li X, Lu X, Huang W, Fan Q, Adv. Mater., 30, 180114 (2018)
  54. Zhu Q, Sun F, Li TL, Zhou M, Ye J, Ji A, Wang H, Ding C, Chen H, Xu Z, Yu H, Small, 17, 200788 (2021)
  55. Welsher K, Liu Z, Sherlock SP, Robinson JT, Chen Z, Daranciang D, Dai HJ, Nat. Nanotechnol., 4(11), 773 (2009)
  56. Hong GS, Diao SO, Antaris AL, Dai HJ, Chem. Rev., 115(19), 10816 (2015)
  57. Tsukasaki Y, Morimatsu M, Nishimura G, Sakata T, Yasuda H, Komatsuzaki A, Watanabe TM, Jin T, RSC Adv., 4, 41164 (2014)
  58. Ma Z, Zhang M, Yue J, Alcazar C, Zhong Y, Doyle TC, Dai H, Huang NF, Adv. Funct. Mater., 28, 180341 (2018)
  59. Hong G, Robinson JT, Zhang Y, Diao S, Antaris L, Wang Q, Dai H, Angew. Chem.-Int. Edit., 51, 9818 (2012)
  60. Li C, Cao L, Zhang Y, Yi P, Wang M, Tan B, Deng Z, Wu D, Wang Q, Small, 11, 4517 (2015)
  61. Park YI, Lee KT, Suh YD, Hyeon T, Chem. Soc. Rev., 44, 1302 (2015)
  62. Naczynski DJ, Tan MC, Zevon M, Wall B, Kohl J, Kulesa A, Chen S, Roth CM, Riman RE, Moghe PV, Nat. Commun., 4, 2199 (2013)
  63. Wang YF, Liu GY, Sun LD, Xiao JW, Zhou JC, Yan CH, ACS Nano, 7, 7200 (2013)
  64. Ren F, Ding L, Liu H, Huang Q, Zhang H, Zhang L, Zeng J, Sun Q, Li Z, Gao M, Biomaterials, 175, 30 (2018)
  65. Zhong Y, Ma Z, Zhu S, et al., Nat. Commun., 8, 737 (2017)
  66. Zhong Y, Ma Z, Wang F, et al., Nat. Biotechnol., 37, 1322 (2019)
  67. Park YI, Nam SH, Kim JH, et al., J. Phys. Chem. C, 117, 2239 (2013)
  68. Chen G, Damasco J, Qiu H, et al., Nano Lett., 15, 7400 (2015)
  69. Shao W, Chen GY, Kuzmin A, Kutscher HL, Pliss A, Ohulchanskyy TY, Prasad PN, J. Am. Chem. Soc., 138(50), 16192 (2016)