화학공학소재연구정보센터
Journal of Industrial and Engineering Chemistry, Vol.102, 135-145, October, 2021
Immobilization of antibacterial copper metal-organic framework containing glutarate and 1,2-bis(4-pyridyl)ethylene ligands on polydimethylsiloxane and its low cytotoxicity
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Metal-organic frameworks (MOFs) that include bioactive metals may exhibit activity against various microbes through metal-ligand bond cleavage to release metal ions or ligands into the media. However, controlled release over an extended time is required to avoid toxicity due to excess metal ions for successful clinical applications. Recently, copper-based MOFs (Cu-MOFs), which showed sustained release capability, porosity, and structural flexibility, exhibited antibacterial properties. Herein, toward the development of regenerative biomedical applications, we immobilized a robust Cu-MOF containing glutarate and 1,2-bis(4-pyridyl)ethylene ligands within biocompatible polydimethylsiloxane (PDMS) via simple hydrosilylation at 25 °C. The PDMS-immobilized Cu-MOF (PDMS@Cu-MOF) exhibited concentration-dependent antibacterial activities against five bacterial strains: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus. Furthermore, PDMS@Cu-MOF maintained the physical and thermal properties of PDMS and showed low cytotoxicity toward mouse embryonic fibroblasts. Owing to its antibacterial properties and low cytotoxicity, PDMS@Cu-MOF exhibited potential for medicinal applications, such as implants, skin disease treatment, wound healing, and drug delivery.
  1. Rosi NL, Eckert J, Eddaoudi M, Vodak DT, Kim J, O’Keeffe M, Yaghi OM, Science, 300, 1127 (2003)
  2. Vornholt SM, Morris RE, Nat. Mater., 18(9), 910 (2019)
  3. Peters AW, Li Z, Farha OK, Hupp JT, A.C.S. Appl, Mater. Interfaces, 8, 20675 (2016)
  4. Lin RB, Liu SY, Ye JW, Li XY, Zhang JP, Adv. Sci., 3, 150043 (2016)
  5. Qin JH, Huang YD, Zhao Y, Yang XG, Li FF, Wang C, Ma LF, Inorg. Chem., 58(22), 15013 (2019)
  6. Hu ML, Razavi SAA, Piroozzadeh M, Morsali A, Inorg. Chem. Front., 7, 1598 (2020)
  7. Liu KG, Rouhani F, Moghanni-Bavil-Olyaei H, Wei XW, Gao XM, Li JZ, Yan XW, Hu ML, Morsali A, J. Mater. Chem. A, 8, 12975 (2020)
  8. Abdollahi N, Razavi SAA, Morsali A, Hu ML, J. Hazard. Mater., 387 (2020)
  9. Qin JH, Zhang H, Sun P, Huang YD, Shen q, Yang XG, Ma LF, Dalton Trans., 49, 17772 (2020)
  10. Liu W, Pan Y, Zhong Y, Li B, Ding Q, Xu H, Qiu Y, Ren F, Li B, Muddassir M, Liu J, Chem. Eng. J., 412 (2021)
  11. Zhong Y, Li X, Chen J, Wang X, Wei L, Fang L, Kumar A, Zhuang S, Liu J, Dalton Trans., 49, 11045 (2020)
  12. Liu Y, Zhou L, Dong Y, Wang R, Pan Y, zhuang S, Liu D, Liu J, Med RSC, Chem. (2021).
  13. Yilgor E, Nugay II, Bakan M, Yilgor I, Silicon, 1, 183 (2009)
  14. Prasse M, Eur. Pat. 1884542, 2008.
  15. Jaros SW, da Silva MFCG, Krol J, Oliveira MC, Smolenski P, Pombeiro AJL, Kirillov AM, Inorg. Chem., 55(4), 1486 (2016)
  16. Wang L, Yang WT, Zhu W, Guan XG, Xie ZG, Sun ZM, Inorg. Chem., 53(21), 11584 (2014)
  17. Lu X, Ye J, Zhang D, Xie R, Bogale RF, Sun Y, Zhao L, Zhao Q, Ning G, J. Inorg. Biochem., 138, 114 (2014)
  18. Restrepo J, Serroukh Z, Santiago-Morales J, Aguado S, Gomez-Sal P, Mosquera MEG, Rosal R, Eur. J. Inorg. Chem., 2017, 574 (2017)
  19. Rubin HN, Neufeld BH, Reynolds MM, A.C.S. Appl, Mater. Interfaces, 10, 15189 (2018)
  20. Sharma VK, Yngard RA, Lin Y, Adv. Colloid Interface Sci., 145, 83 (2009)
  21. Li HB, Duan XC, Liu GC, Liu XQ, J. Mater. Sci., 43(5), 1669 (2008)
  22. Zeng HD, Zhao CJ, Qiu JR, Yang YX, Chen GR, J. Cryst. Growth, 300(2), 519 (2007)
  23. Dadgar N, Ghiaseddin A, Irani S, Rabbani S, Tafti SHA, Soufizomorrod M, Soleimani M, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 120 (2021)
  24. Dadgar N, Ghiaseddin A, Irani S, Tafti SHA, Soufi-Zomorrod M, Soleimani M, J. Biomater. Appl., 35, 1315 (2021)
  25. Munoz-Bonilla A, Fernandez-Garcia M, Prog. Polym. Sci., 37, 281 (2012)
  26. Elist JJ, Shirvanian V, Lemperle G, Open, J. Urol., 4, 91 (2014)
  27. Teo AJT, Mishra A, Park I, Kim YJ, Park WT, Yoon YJ, A.C.S. Biomater, Sci. Eng., 2, 454 (2016).
  28. Yilgor E, Yilgor I, Prog. Polym. Sci, 39, 1165 (2014)
  29. Rahimi A, Mashak A, Plast. Rubber Compos., 42, 223 (2013)
  30. Lachhman S, Zorman CA, Ko WH, Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp1655 2012.
  31. Chanda M, Plastics Technology Handbook, fifth ed., CRC Press, Boca Raton, FL, USA, 2018.
  32. Islas MS, Medina JJM, Tevez LLL, Rojo T, Lezama L, Merino MG, Calleros L, Cortes MA, Puyol MR, Echeverria GA, Piro OE, Ferrer EG, Williams PAM, Inorg. Chem., 53(11), 5724 (2014)
  33. Chen Y, Han Q, Wang Y, Zhang Q, Qiao X, J. Appl. Polym. Sci., 132, 41723 (2015)
  34. Jon´ ca J, Tukaj C, Werel W, Mizerska U, Fortuniak W, Chojnowski J, J. Mater. Sci. -Mater. Med., 27, 55 (2016)
  35. Chojnowski J, Fortuniak W, Ros´ciszewski P, Werel W, Łukasiak J, Kamysz W, Hałasa R, J. Inorg. Organomet. Polym. Mater., 16, 219 (2006)
  36. Mansouri J, Truong VK, MacLaughlin S, Mainwaring DE, Moad G, Dagley IJ, Ivanova EP, Crawford RJ, Chen V, Nanomaterials, 9, 1610 (2019)
  37. Mizerska U, Fortuniak W, Chojnowski J, Hałasa R, Konopacka A, Werel W, Eur. Polym. J., 45, 779 (2009)
  38. Rozga-Wijas K, Mizerska U, Fortuniak W, Chojnowski J, Hałasa R, Werel W, J. Inorg. Organomet. Polym. Mater., 17, 605 (2007)
  39. Staszek M, Siegel J, Kolarˇova K, Rimpelova S, Svorciik V, Micro Nano Lett., 9, 778 (2014)
  40. Calderon JAG, Lopez DC, Perez E, Montesinos JV, Polym. Bull., 77(5), 2749 (2020)
  41. Jo JH, Kim HC, Huh S, Kim Y, Lee DN, Dalton Trans., 48, 8084 (2019)
  42. Gwon K, Kim Y, Cho H, Lee S, Yang SH, Kim SJ, Lee DN, Nanomaterials, 11, 719 (2021)
  43. Gwon K, Han I, Lee S, Kim Y, Lee DN, A.C.S. Appl, Mater. Interfaces, 12, 20234 (2020)
  44. Gwon K, Jo EJ, Sahu A, Lee JY, Kim MG, Tae G, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 90, 77 (2018)
  45. Cheng X, Liu J, Wang L, Wang R, Liu Z, Zhuo R, RSC Adv., 6, 101334 (2016)
  46. Meister TL, Riener K, Gigler P, Stohrer J, Herrmann WA, Kuhn FE, ACS Catal., 6, 1274 (2016)
  47. Nakajima Y, Shimada S, RSC Adv., 5, 20603 (2015)
  48. Rensing C, Fan B, Sharma R, Mitra B, Rosen BP, Proc. Nat. Acad. Sci., 97, 652 (2000)
  49. Andreini C, Banci L, Bertini I, Rosato A, J. Proteome Res., 7, 209 (2008)
  50. Festa RA, Thiele DJ, Curr. Biol., 21, R877 (2011)
  51. Giachino A, Waldron KJ, Mol. Microbiol., 114, 377 (2020)
  52. Duan C, Meng X, Liu C, Lu W, Liu J, Dai L, Wang W, Zhao W, Xiong C, Ni Y, Carbohydr. Polym., 222 (2019)
  53. Emam HE, Darwesh OM, Abdelhameed RM, Colloids Surf. B: Biointerfaces, 165, 219 (2018)
  54. WylesCC, Paradise CR, Masters TL, Patel R, van Wijnen AJ, Abdel MP, Trousdale RT, Sierra RJ, J. Arthroplasty, 35, 1123 (2020)