Journal of Chemical and Engineering Data, Vol.66, No.1, 684-691, 2021
Solubilities of Oleanolic Acid and Ursolic Acid in Different Organic Solvents and 2-Propanol + Water Binary Solvent Mixtures at Different Temperatures: Experimental Measurement and Modeling
The solubilities of oleanolic acid and ursolic acid in 1-butanol, methyl isobutyl ketone, methyl tert-butyl ether, and 2-propanol + water binary solvent systems at different temperatures were determined by a high-performance liquid chromatography analysis method. Various models were used to fit the solubility data; the results showed that the modified Apelblat mode can best fit the solubility data with temperature among the three modes (the modified Apelblat mode, the lambda h equation, and the van't Hoff equation), and the Ma model gave a better correlation of the solubility data with both the temperature and mole fraction of 2-propanol in the binary solvent mixture than the Sun model. The experimental solubility data and computational model can be useful for separation and purification of oleanolic acid and ursolic acid.