Applied Microbiology and Biotechnology, Vol.104, No.18, 7657-7671, 2020
Engineering the gut microbiota to treat chronic diseases
Gut microbes play vital roles in host health and disease. A number of commensal bacteria have been used as vectors for genetic engineering to create living therapeutics. This review highlights recent advances in engineering gut bacteria for the treatment of chronic diseases such as metabolic diseases, cancer, inflammatory bowel diseases, and autoimmune disorders.