화학공학소재연구정보센터
Applied Microbiology and Biotechnology, Vol.104, No.23, 9907-9920, 2020
Recent advances in biocatalytic derivatization ofl-tyrosine
l-Tyrosine is an aromatic, polar, non-essential amino acid that contains a highly reactive alpha-amino, alpha-carboxyl, and phenolic hydroxyl group. Derivatization of these functional groups can produce chemicals, such asl-3,4-dihydroxyphenylalanine, tyramine, 4-hydroxyphenylpyruvic acid, and benzylisoquinoline alkaloids, which are widely employed in the pharmaceutical, food, and cosmetics industries. In this review, we summarize typicall-tyrosine derivatizations catalyzed by enzymatic biocatalysts, as well as the strategies and challenges associated with their production processes. Finally, we discuss future perspectives pertaining to the enzymatic production ofl-tyrosine derivatives.