화학공학소재연구정보센터
Polymer(Korea), Vol.45, No.1, 79-88, January, 2021
고분자 마이셀을 이용한 레티놀 제형개발: 레티놀 안정성
Development of Retinol-loaded Polymeric Micelle: Stability of Retinol
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초록
레티놀은 빛, 열 및 산소에 대해 불안정하다는 특징이 있어 레티놀에 대한 안정화 기술이 계속해서 요구되고 있다. 이러한 추세에 따라 안정성이 개선된 레티놀 폴리머 마이셀 연구를 수행하게 되었다. 레티놀 조성에 산화방지제를 함량별 첨가하였고 입도 측정, 장기 및 가속 안정성, 피부투과 등 실험을 진행하였다. 입자 크기는 산화방지제 함량에 따라 차이를 나타내었다. 이 중 레티놀과 butylated hydroxyanisole(BHA) 비율이 1:1인 M3 조성은 80.83% 및 81.18%의 장기 및 가속안정성을 나타내었다. 이 제형을 대상으로 피부투과 실험을 진행하였을 때, 대조군으로 사용된 S 1보다 M3의 피부투과율(52.8%)이 더 크게 나타났다. 종합적으로 레티놀 안정성을 개선할 수 있는 산화방지제와 계면활성제의 적합한 비율을 확립하였다.
Retinol is unstable to the external environment and its properties can deteriorate. Therefore, new stabilization techniques for retinol are needed. According to this trend, a lot of research to improve the stability of retinol is ongoing. Antioxidants were added to the core part of the retinol polymeric micelle particle by content. After preparting the retinol micelle formulation with antioxidants by content, experiments such as particle size measurement, long-term and accelerated stability test, and skin permeation were performed. The micelle particle size depended on the antioxidant ratio. The retinol proportion of M3 composition with a ratio of retinol to butylated hydroxyanisole (BHA) of 1:1 did not show any change in both long-term stability test (80.83%) and accelerated stability test (81.18%). Skin permeation experiments were performed on this formulation. As a result, the skin permeability of M3 (52.8%) was greater than that of S1 used as a control. As a comprehensive result, retinol stability was improved by establishing an appropriate ratio of antioxidants and surfactants.
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